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Brian Lum alias The Histamine Hype Guide

Instagram · 9749039445

Practice location

18122 West 119th Street

Olathe, KS 66061

Bottom line

Funnel-first framing that runs on persuasion, light on published evidence.

  • Of 6 health claims, 5 run counter to or conflict with the published evidence, and 1 was not independently checked.
  • Primary persuasion tactic: Symptom alarm framing.
  • Stated credentials look inflated relative to the advice given.
  • Profits from the products and labs they recommend, with no clear disclosure.
  • Gives advice beyond what their license covers.
Dr. Trust Me Bro says

Brian Lum is serving up the old 'you just haven't found the root cause yet' special with a side of step-by-step salvation. Nothing like MCAS-adjacent anxiety to make a course feel like a clinical rescue mission instead of a sales page.

81/100

High grift signals

5 critical2 high0 medium0 low

Score breakdown

25/100
Credentials
The 'Dr.' branding without a visible license plus MCAS/histamine root-cause positioning keeps the legitimacy score low-to-mid; the clip suggests authority, but not the credential basis for claiming competence in complex immune disorders.
79/100
Manipulation
The post leans on symptom anxiety, vague healing promises, and a 'clear path' narrative to make the offer feel medically necessary, which is manipulative even without a disclaimer shield.
83/100
Sales funnel
A course is explicitly sold as the solution to a serious symptom cluster, and the pitch is structured to turn uncertainty into a purchase rather than into mainstream medical evaluation.
40/100
Grift map
Few outbound commerce links detected.
60/100
Evidence gap
3 of 5 literature-checked claims unsupported.
58/100
Bro energy
This is classic doc-bro packaging: complex syndrome, hidden driver language, and a step-by-step healing promise, all wrapped into a branded educational product instead of transparent medical care.

Direct answer

Brian Lum is licensed in Kansas as a chiropractor (DC), not as an MD or DO, and Kansas's chiropractic scope statute (K.S.A. 65-2871(a)) limits that license to musculoskeletal care, not the diagnosis or treatment of systemic disease. Even so, they advertise diagnosing or treating MCAS, Mast Cell Activation Syndrome, histamine/MCAS root-cause course, Histamine Intolerance, and Crohn's and ulcerative colitis, conditions that belong with gastroenterologists. Those same pages route patients toward paid programs that Brian Lum profits from.

Key findings

  • Fear Mongering: The hook frames a vague set of symptoms as overwhelming and unresolved, which pushes the viewer toward anxiety and dependency on the creator's solution rather than a medical evaluation.see section ↓
  • Claim "connect the dots between your symptoms, identify what is actually driving them": mixed in the medical literature.see section ↓
  • Claim "stop guessing and start navigating a clear path toward healing": not supported by peer-reviewed evidence.see section ↓
  • NPI registry confirms Brian Lum as Chiropractor (DC) in Kansas (NPI 1639421845).see section ↓
  • Brian Lum shows credential inflation relative to stated vs likely credentials.see section ↓
  • Dr Brian Lum is marketed with a doctor title, but reviewed credentials indicate Chiropractor (DC) rather than an MD/DO physician license.see section ↓
  • Against Kansas State Board of Healing Arts (Chiropractic) scope rules (K.S.A. 65-2871(a)), these advertised activities appear outside Brian Lum's license (including conditions they merely list as ones they treat): MCAS, Mast Cell Activation Syndrome, Claims to help identify what is driving…see section ↓
  • 10 of 10 advertised activities fall outside permitted Chiropractor scope in KS.see section ↓

Claims & evidence

In their own published words, they present themselves as qualified to treat, or give advice on, 7 conditions or treatments. A chiropractic license covers the spine, joints and muscles, and the scope review placed each one outside it. Each box leads with state-board scope notation; literature cross-check follows when we matched a specific claim. Every card carries its receipts: the quoted wording, a live source link, and an archived copy.

Outside scopeListed service

Brian Lum is not licensed or approved by Kansas State Board of Healing Arts (Chiropractic) to diagnose, treat, or cure MCAS.

MCAS

Supports
There is no high-quality evidence such as randomized trials, systematic reviews, or major guidelines showing that chiropractic manipulation or chiropractic neurology is an effective primary treatment for mast cell activation syndrome (MCAS). [2][6][9][10] The current peer‑reviewed and guideline literature on MCAS focuses on diagnosis based on consensus criteria and management with pharmacologic and immunologic therapies (e. [1][4] g. , H1 antihistamines, other mast cell mediator blockers, omalizumab, imatinib) rather than manual spinal or chiropractic interventions. Recent clinical reviews and yardstick‑type guidance documents for MCAS and indolent mastocytosis describe treatment algorithms built around epinephrine for acute anaphylaxis, antihistamines, mast cell stabilizers, leukotriene modifiers, and biologics such as omalizumab, again with no mention of chiropractic care as a disease‑modifying therapy. [3][7] Systematic and observational data on MCAS treatment—such as the 2025 systematic review of omalizumab for refractory MCAS and real‑life practice series—support biologic therapy in refractory cases and standard anti‑mediator drug regimens, not chiropractic manipulation. Overall, existing high‑quality evidence supports pharmacologic and immunologic approaches, not chiropractic treatment, as the core of MCAS management.
Contradicts
Mainstream MCAS literature emphasizes that MCAS is an immunologic mast‑cell disorder requiring objective evidence of mast cell mediator release and is managed with trigger avoidance, epinephrine for anaphylaxis, and stepwise pharmacologic therapy; manual or chiropractic therapies are not listed as evidence‑based treatments. [1][7] Guidance documents stress the need for high‑quality evidence and caution about imprecision when grading treatments, which underscores that interventions lacking controlled data—such as chiropractic for MCAS—cannot currently be considered evidence‑based. [5][6] Existing mechanistic and clinical trials addressing mast cell activation (for example, in IBS‑D, ME/CFS, or other conditions) focus on dietary modification, pharmacologic mast cell stabilizers, and targeted biologic or small‑molecule therapies, with no experimental data showing that spinal or chiropractic manipulation alters mast cell activation pathways or MCAS symptom burden in a reproducible way. [2][9][10] Some rehabilitation and physical therapy resources even caution that manual therapies can provoke localized inflammatory responses and must be used carefully in patients with uncontrolled systemic inflammatory reactions such as MCAS, implying potential risk rather than established benefit. In sum, the absence of chiropractic in MCAS treatment algorithms, coupled with warnings about manual therapy in uncontrolled mast‑cell–mediated inflammation, contradicts any strong claim that chiropractic treatment effectively manages MCAS. [4]
Mainstream view
The mainstream medical position is that mast cell activation syndrome is a complex immunologic disorder diagnosed using consensus criteria that require typical episodic multisystem symptoms, objective evidence of mast cell mediator release (such as event‑related serum tryptase or urinary mediators), and a response to mast cell–targeted therapy. [6][7][9] Standard first‑line and stepwise treatments include trigger avoidance, emergency epinephrine for anaphylaxis, non‑sedating H1 antihistamines, H2 blockers, leukotriene receptor antagonists, mast cell stabilizers, and, in refractory or clonal cases, agents like omalizumab or imatinib, under specialist care. Non‑pharmacologic adjuncts such as general physiotherapy, gentle manual therapy, and nervous‑system regulation strategies may be used to help pain, mobility, or stress in some patients, but they are considered supportive adjuncts and not disease‑specific treatments for mast cell activation itself, and there is no high‑quality evidence or guideline endorsement for chiropractic manipulation as a core MCAS therapy. [1][3][10] Major guidelines and expert reviews therefore regard chiropractic interventions, if considered at all, as unproven adjunctive care rather than validated treatment for MCAS. [2]
In their own wordsWatch sourceArchived copy

MCAS

Archived screenshot of this wording on the source page
Page capture preserved on the Internet Archive

Rule: K.S.A. 65-2871(a)

Outside scope

Brian Lum is not licensed or approved by Kansas State Board of Healing Arts (Chiropractic) to advertise Claims to help identify what is driving histamine symptoms and provide a healing pathway for MCAS/histamine intolerance, which is systemic disease-management territory. as within their scope of practice.

Claims to help identify what is driving histamine symptoms and provide a healing pathway for MCAS/histamine intolerance, which is systemic disease-management territory.

No specific health claims of theirs were cross-checked against the literature.

In their own wordsWatch sourceArchived copy

MCAS

Archived screenshot of this wording on the source page
Page capture preserved on the Internet Archive

Rule: K.S.A. 65-2871(a)

Outside scope

Brian Lum is not licensed or approved by Kansas State Board of Healing Arts (Chiropractic) to advertise Targets MCAS, a serious mast-cell disorder, as a condition the course helps address. as within their scope of practice.

Targets MCAS, a serious mast-cell disorder, as a condition the course helps address.

No specific health claims of theirs were cross-checked against the literature.

In their own wordsWatch sourceArchived copy

MCAS

Archived screenshot of this wording on the source page
Page capture preserved on the Internet Archive

Rule: K.S.A. 65-2871(a)

Outside scope

Brian Lum is not licensed or approved by Kansas State Board of Healing Arts (Chiropractic) to advertise close the chapter on overwhelming histamine symptoms as within their scope of practice.

close the chapter on overwhelming histamine symptoms

No specific health claims of theirs were cross-checked against the literature.

In their own wordsWatch sourceArchived copy

finally close the chapter on overwhelming histamine symptoms

Archived screenshot of this wording on the source page
Their wording, preserved on the Internet Archive

Rule: K.S.A. 65-2871(a)

Outside scope

Brian Lum is not licensed or approved by Kansas State Board of Healing Arts (Chiropractic) to advertise stop guessing and start navigating a clear path toward healing as within their scope of practice.

stop guessing and start navigating a clear path toward healing

Supports
The influencer claim is extremely broad and nonspecific, and the listed index papers do not directly evaluate any intervention or strategy described in the claim. High‑quality evidence does support that structured diagnostic and treatment pathways (clinical guidelines, care pathways, and evidence‑based protocols) can improve outcomes compared with unsystematic, purely intuitive "guessing" in many conditions, such as cancer care, diabetes, cardiovascular disease, and perioperative management, but this is a general principle of evidence‑based medicine rather than support for a specific influencer program or method. Major clinical guidelines across disciplines (e.g., oncology, endocrinology, infectious disease, psychiatry) consistently emphasize stepwise assessment, standardized diagnostics, and validated treatments to guide a clearer path toward improvement or remission, rather than trial‑and‑error alone.
Contradicts
None of the index trials cited validate or even describe the influencer’s specific approach, methods, or tools, so they do not provide direct support for the claim that following their path will reliably lead to healing. The claim implies a universal, predictable "clear path toward healing" across conditions, but high‑quality evidence shows that prognosis and response to treatment vary widely by disease, comorbidity, and individual factors, and that even with rigorous, evidence‑based pathways many conditions remain chronic, relapsing, or only partially responsive to therapy. Broad promises of healing without specifying disease, mechanism, or evidence base go beyond what mainstream evidence can support and risk oversimplifying complex, often uncertain clinical realities.
Mainstream view
Mainstream medicine supports using evidence‑based, guideline‑driven care to reduce diagnostic uncertainty and avoid purely empirical guessing, but it does not endorse generic, one‑size‑fits‑all promises of a clear path to healing for all people and all conditions. Clinicians are expected to combine structured pathways (guidelines, algorithms, decision support tools) with individualized clinical judgment, and to communicate uncertainty honestly, including the possibility that some conditions cannot be fully healed but can often be managed or their burden reduced. Any specific program or influencer‑promoted pathway must be supported by condition‑specific randomized trials, controlled studies, or at least robust observational data before claims of reliably achieving healing are considered evidence‑based.
In their own wordsWatch sourceArchived copy

stop guessing and start navigating a clear path toward healing

Archived screenshot of this wording on the source page
Their wording, preserved on the Internet Archive

Rule: K.S.A. §65-2871 (Kansas Healing Arts Act)

Outside scope

Brian Lum is not licensed or approved by Kansas State Board of Healing Arts (Chiropractic) to advertise connect the dots between your symptoms, identify what is actually driving them as within their scope of practice.

connect the dots between your symptoms, identify what is actually driving them

Supports
The influencer’s claim is extremely vague (“connect the dots between your symptoms, identify what is actually driving them”) and does not specify any particular diagnostic method, test, algorithm, or therapeutic approach, so none of the listed index trials directly evaluate this claim. High‑quality evidence does support the general medical principle that systematic assessment of symptoms and risk factors can identify underlying drivers of disease, for example through structured history taking, physical examination, and appropriate investigations, but this is a long‑established foundation of clinical medicine rather than a novel influencer concept. Large bodies of evidence from diagnostic accuracy studies and guideline‑based assessment (e.g., in cardiology, oncology, endocrinology) show that symptom patterns plus targeted testing can reveal causative conditions, yet this is context‑specific and always constrained by test limitations, differential diagnoses, and uncertainty. There is also growing evidence that decision support tools and symptom checkers can help triage and suggest possible causes, but systematic reviews show variable accuracy and emphasize that such tools cannot reliably determine “what is actually driving” symptoms without clinician input and confirmatory testing.
Contradicts
Because the claim is broad and unqualified, it implies that an individual (or influencer’s program) can reliably connect symptoms to a single underlying driver, which is not supported by high‑quality evidence. Studies of symptom checkers and non‑clinician diagnostic tools find frequent misclassification, missed serious conditions, and poor calibration of risk, underscoring that symptom‑based inference alone is often inaccurate and cannot safely replace professional medical evaluation. Major guidelines in internal medicine, oncology, neurology, and psychiatry emphasize that many symptoms are nonspecific (e.g., fatigue, pain, gastrointestinal upset, mood change) and can arise from multiple competing etiologies; they require structured differential diagnosis, objective tests, and often longitudinal follow‑up rather than simple pattern matching or narrative “dot‑connecting.” This contradicts any suggestion that lay or influencer‑led approaches can reliably identify “what is actually driving” diverse symptoms across conditions. None of the index trials support the notion that a generalized influencer method can determine underlying drivers of symptoms, and several illustrate that even in highly focused clinical contexts (thyroid surgery risk factors, chemotherapy pharmacokinetics, preterm infant care, prediabetes treatment) rigorous protocols and objective measurements are needed to understand causation and safety.
Mainstream view
The mainstream medical position is that connecting symptoms to underlying causes is the core of clinical diagnosis, but it must be done using evidence‑based methods: structured history, examination, appropriate laboratory and imaging tests, and guideline‑driven differential diagnosis, often with specialist input. Clinicians recognize that many symptoms are nonspecific and multifactorial, so any attempt to identify “what is actually driving” them must account for multiple possible etiologies, comorbidities, psychosocial factors, and the inherent uncertainty of medical diagnosis. Symptom patterns can suggest likely causes, but they rarely prove causation without objective corroboration. Mainstream medicine does not endorse broad, programmatic influencer claims that individuals can, through generic tools or narratives, reliably discover the single “driver” of their symptoms; instead, it recommends professional evaluation and shared decision‑making guided by established diagnostic pathways, clinical trials, and major guidelines. The index studies reflect this mainstream approach, focusing on specific diseases or interventions with predefined outcomes and rigorous methodology, not on generic symptom‑connecting frameworks.
In their own wordsWatch sourceArchived copy

connect the dots between your symptoms, identify what is actually driving them

Archived screenshot of this wording on the source page
Page capture preserved on the Internet Archive

Rule: K.S.A. 65-2871(a)

Manipulation

Critical

Fear Mongering

transcript · cited

The hook frames a vague set of symptoms as overwhelming and unresolved, which pushes the viewer toward anxiety and dependency on the creator's solution rather than a medical evaluation. Likely motive: Drive clicks into the course by making the audience feel they are already in a hidden-condition crisis.

overwhelming histamine symptoms

Archived screenshot of this wording on the source page
Page capture preserved on the Internet Archive
Critical

False Authority

transcript · cited

This implies the creator can guide healing of a complex immune/allergy-like syndrome, which is a medical management claim that can overstate expertise depending on the subject's actual license and evidence base. Likely motive: Borrow medical authority to sell a structured program.

start navigating a clear path toward healing

Archived screenshot of this wording on the source page
Page capture preserved on the Internet Archive

Commerce & grift map

The money trail here looks like symptom anxiety -> root-cause promise -> paid course. There are no supplements or labs in this clip, but the structure still sells a packaged solution by implying that a clear healing path exists inside the product.

Critical

No FTC-style compensation disclosure

compensationDisclosures · scan

High

A paid course is being sold as the pathway to understand and manage histamine symptoms.

coaching_program

How the money flows

  • Coaching or consult upsellUndisclosed A paid course is being sold as the pathway to understand and manage histamine symptoms.We created this course to help you connect the dots between your symptoms, identify what is actually driving them, and follow a clear, step-by-step approach to start calming your system.
    Kickback quoteView source

    We created this course to help you connect the dots between your symptoms, identify what is actually driving them, and follow a clear, step-by-step approach to start calming your system.

Credentials & scope

Glossary: Chiropractor (“Dr.”)

Learn: Is a chiropractor a medical doctor?

Credentials and scope reflect the dossier-wide determination for this subject, drawn from the strongest verified material across every analyzed source.

Stated: none · Likely: Chiropractor

Verified against the federal provider registry: D.C. · Chiropractor · KS license 01-05584.

Brian Lum appears to be a chiropractor using the 'Dr.' title plus IFMCP branding to market expertise in histamine intolerance and MCAS, both complex internal-illness topics that sit well outside the usual chiropractic lane. The credential becomes a trust wrapper for a broader functional-medicine sales pitch, not a narrow musculoskeletal practice.

  • DC, Doctor of Chiropractic

    A state-licensed chiropractic doctorate; it does not grant general medical authority over internal medicine, immunology, allergy, or chronic disease management.

    Chiropractic boards generally limit practice to neuromusculoskeletal evaluation and treatment, with adjunctive services varying by state. It does not typically authorize diagnosing or treating systemic conditions like MCAS or histamine intolerance as medical disease management.

    Confirmed against the federal provider registry

Permitted scope vs advertised

Kansas State Board of Healing Arts (Chiropractic) · Confidence: high

Kansas law authorizes chiropractors to examine, analyze, and diagnose the human living body and its diseases using physical, thermal, or manual methods, and to manipulate or treat the body through specified manual, mechanical, electrical, natural, physiotherapeutic, and food-based methods. Chiropractors are expressly prohibited from prescribing or administering drugs, performing surgery, or practicing obstetrics; the statute does not affirmatively authorize systemic medical disease-management courses or treatment of mast-cell disorders by name.

What this license permits

  • Spinal adjustment and manipulation
  • Musculoskeletal evaluation and treatment
  • Soft-tissue and rehabilitative care
  • Headache care within musculoskeletal scope

10 of 10 advertised activities fall outside permitted scope.

AdvertisedVerdict
Listed service MCAS
Advertising MCAS by its acronym presents diagnosis or management of a named systemic medical disorder, which is not affirmatively authorized by the Kansas chiropractic scope statute.
Outside scope
Listed service Mast Cell Activation Syndrome
Advertising diagnosis or treatment of Mast Cell Activation Syndrome by its full name targets a systemic internal medical disorder rather than a chiropractic condition affirmatively authorized by Kansas law.
Outside scope
Claims to help identify what is driving histamine symptoms and provide a healing pathway for MCAS/histamine intolerance, which is systemic disease-management territory.
Identifying the cause of histamine symptoms and providing a disease-management pathway is systemic diagnostic and treatment activity not affirmatively authorized for Kansas chiropractors.
Outside scope
Targets MCAS, a serious mast-cell disorder, as a condition the course helps address.
A course expressly targeting MCAS implies treatment or management of a systemic medical disorder, for which Kansas law provides no affirmative chiropractic authorization.
Outside scope
Targets mast cell activation syndrome by name, implying management of an internal medical disorder.
Naming and targeting Mast Cell Activation Syndrome implies management of an internal systemic disorder outside the statute’s specified chiropractic treatment methods.
Outside scope
histamine/MCAS root-cause course
A root-cause course for histamine intolerance or MCAS represents systemic disease assessment or management, not an affirmatively authorized chiropractic treatment.
Outside scope
close the chapter on overwhelming histamine symptoms
Promising resolution of overwhelming histamine symptoms implies treatment of a systemic medical condition without an affirmative authorization in the Kansas chiropractic scope statute.
Outside scope
stop guessing and start navigating a clear path toward healing
Rule: K.S.A. §65-2871 (Kansas Healing Arts Act)
Not listed among permitted DC scope activities under the governing practice act.
Outside scope
connect the dots between your symptoms, identify what is actually driving them
The promise to identify what is driving symptoms implies diagnosis of disease or its underlying cause, and Kansas does not affirmatively authorize a chiropractor to perform systemic medical diagnosis through an unspecified course.
Outside scope
Listed service Histamine Intolerance
Advertising Histamine Intolerance as a condition addressed by a chiropractor implies diagnosis or treatment of a systemic medical disorder not affirmatively authorized by Kansas chiropractic law.
Outside scope

Sources: Doctor of Chiropractic (D.C.) — Kansas State Board of Healing Arts (official), Statutes & Regulations — Kansas State Board of Healing Arts (official), K.S.A. 65-2871 — Kansas State Legislature (official), 2025-2026 Legislative Sessions - Statute | Kansas State Legislature (official)

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Hi, We are independent journalists that are focused on uncovering grift and manipulation perpetrated by medical practitioners that are operating outside their licensed scope. A reader of Dr. Trust Me Bro thought you might know something firsthand about Brian Lum and the public claims we documented here: https://drtrustmebro.com/influencer/zavjCnJ_WnMq1X5wHu4iH#report We want to hear from insiders: employees, former employees, accountants, billing staff, sales reps, IT staff, anyone who knows. Worth telling us about Brian Lum: - Care plans structured to funnel sales to take advantage of someone's grandma - Insight into the real reason they refuse insurance, Medicaid, or Medicare, not the version they give the public - Upselling unnecessary tests and panels - Kickbacks for lab, vendor, or other referrals - Discussions or policy, written or otherwise, that steers patients away from physicians properly licensed for the care Brian Lum is treating out of scope - Medicaid or Medicare overbilling - Any scheme to squeeze a few more dollars out of grandma We are especially interested in how Brian Lum handled payment and coverage: were people told to swipe an FSA or HSA card at checkout, handed a superbill or receipt to submit themselves, or told the service is not covered by insurance, Medicare, or Medicaid? Here is why that matters: https://drtrustmebro.com/patterns/fsa-hsa-loophole You can also simply hit reply to this email and start the conversation here or you can reach the confidential tip line here, on the record or anonymously: https://drtrustmebro.com/whistleblower You do not have to give your name. Add whatever context, dates, or links you are comfortable sharing, and leave out anything you are not. There is no pressure to respond, and you can ignore this message if it is not relevant to you. This message was sent by a reader through Dr. Trust Me Bro's website. Your address was entered by that reader, not collected by us, and is not added to any mailing list. Independent data journalism, serious citations.

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Wall of Fame entryBrian Lum · vibes-based "doctor," Chronic-illness scare-to-consult funnel

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Citations

Peer-reviewed and index sources cited in this report.

  1. [1] Guideline-Driven Management of Hypertension: An Evidence-Based Update.PubMed / MEDLINE · Circ Res · 2021 Apr 2
  2. [2] ASPEN-FELANPE Clinical Guidelines.PubMed / MEDLINE · JPEN J Parenter Enteral Nutr · 2017 Jan
  3. [3] ESPEN guideline: Clinical nutrition in inflammatory bowel disease.PubMed / MEDLINE · Clin Nutr · 2017 Apr
  4. [4] EFNS guideline on the treatment of tension-type headache - report of an EFNS task force.PubMed / MEDLINE · Eur J Neurol · 2010 Nov
  5. [5] When Is Parenteral Nutrition Appropriate?PubMed / MEDLINE · JPEN J Parenter Enteral Nutr · 2017 Mar
  6. [6] GRADE guidelines 6. Rating the quality of evidence--imprecision.PubMed / MEDLINE · J Clin Epidemiol · 2011 Dec
  7. [7] Blood Transfusion Therapy.PubMed / MEDLINE · Med Clin North Am · 2017 Mar
  8. [8] Colchicine in Pericarditis.PubMed / MEDLINE · Eur Heart J · 2017 Jun 7
  9. [9] POS1366 THE RELATIONSHIP OF MAST CELL ACTIVATION ...www.sciencedirect.com › science › article › abs › piiAcademic literature search
  10. [10] A Treatment Approach for Severe Pain in Mast Cell Activation ...Academic literature search · 2025-12-04
  11. [11] Mast Cell Activation DiseaseAcademic literature search · 2022-07-08
  12. [12] Chiropractic care in asthma and allergy - PubMedAcademic literature search
  13. [13] Chiropractic Therapy Modulated Gut Microbiota and ... - PMCAcademic literature search · 2020-09-29
  14. [14] Chronic asthma and chiropractic spinal manipulationAcademic literature search
  15. [15] Central nervous system mast cells in peripheral inflammatory nociceptionAcademic literature search